abstract：:Leukocyte migration across the endothelial barrier plays an essential role in CNS inflammation. The migration process requires complex endothelial adhesion molecules concentrated at the junctions of endothelial cells. Recent findings suggest that cerebral endothelial cells play an active role in the pathogenesis of CN...

journal_title：Journal of leukocyte biology

authors： Wu F,Liu L,Zhou H

更新日期：2017-05-01 00:00:00

abstract：:Precursors of dendritic cells (pre-DCs) arise in the bone marrow (BM), egress to the blood, and finally migrate to peripheral tissue, where they differentiate to conventional dendritic cells (cDCs). Upon their activation, antigen-bearing cDCs migrate from peripheral tissue to regional lymph nodes (LNs) in a manner dep...

journal_title：Journal of leukocyte biology

authors： Nakano H,Lyons-Cohen MR,Whitehead GS,Nakano K,Cook DN

更新日期：2017-05-01 00:00:00

abstract：:Compared with CD4+25+ regulatory T cells (Tregs), the mechanisms for natural, polyclonal CD8+25+ Treg immune suppression have been significantly less studied. We previously showed that polyclonal T cells can acquire antigen-specific targeting activity through arming with exosomal peptide-MHC (pMHC). In this study, we ...

journal_title：Journal of leukocyte biology

authors： Mu C,Zhang X,Wang L,Xu A,Ahmed KA,Pang X,Chibbar R,Freywald A,Huang J,Zhu Y,Xiang J

更新日期：2017-05-01 00:00:00

abstract：:Histone acetylation has an important role in gene regulation, DNA replication, and repair. Because these processes are central to the development of the immune system, we investigated the role of a previously unstudied histone acetyltransferase named KAT7 (also known as Myst2 or HBO1) in the regulation of thymopoiesis...

journal_title：Journal of leukocyte biology

authors： Newman DM,Voss AK,Thomas T,Allan RS

更新日期：2017-04-01 00:00:00

abstract：:The adhesion and degranulation promoting adaptor protein (ADAP) is a multifunctional scaffold involved in many different signaling pathways that are important for the function of T cells, including the inside-out and outside-in signaling of integrins, the activation of NF-κB, and the subsequent production of proinflam...

journal_title：Journal of leukocyte biology

authors： Parzmair GP,Gereke M,Haberkorn O,Annemann M,Podlasly L,Kliche S,Reinhold A,Schraven B,Bruder D

更新日期：2017-02-01 00:00:00

abstract：:PI3Ks have been identified as key signaling proteins involved in many basic biologic processes in health and disease. Transgenic animals have been essential tools to study the underlying molecular mechanisms in this context and therefore, have been widely used to elucidate the role of these factors in many different s...

journal_title：Journal of leukocyte biology

authors： Schneider C,Nobs SP,Heer AK,Hirsch E,Penninger J,Siggs OM,Kopf M

更新日期：2017-02-01 00:00:00

abstract：:Cellular lysates from PPD+ donors have been reported to transfer tuberculin reactivity to naïve recipients, but not diphtheria reactivity, and vice versa. A historically controversial topic, the terms "transfer factor" and "DLE" were used to characterize the reactivity-transferring properties of lysates. Intrigued by ...

journal_title：Journal of leukocyte biology

authors： Myles IA,Zhao M,Nardone G,Olano LR,Reckhow JD,Saleem D,Break TJ,Lionakis MS,Myers TG,Gardina PJ,Kirkpatrick CH,Holland SM,Datta SK

更新日期：2017-01-01 00:00:00

abstract：:Cytokines of the GM-CSF family signal via the same receptor subunit (βc) and, thus, have overlapping effects on cells that express all cytokine-specific α-chains (IL-3Rα, IL-5Rα, GM-CSFRα), such as human basophils, whose rapid effector functions are similarly enhanced by IL-3, IL-5, and GM-CSF. However, previous work ...

journal_title：Journal of leukocyte biology

authors： Kämpfer SS,Odermatt A,Dahinden CA,Fux M

更新日期：2017-01-01 00:00:00

abstract：:Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion-related acute lung injury (TRALI). LysoPCs cause ligation of the G2A receptor, cytosolic Ca2+ flux, and activation of Hck. We hypothesize that lysoPCs induce Hck-dependent activation of protein ...

journal_title：Journal of leukocyte biology

authors： Kelher MR,McLaughlin NJ,Banerjee A,Elzi DJ,Gamboni F,Khan SY,Meng X,Mitra S,Silliman CC

更新日期：2017-01-01 00:00:00

abstract：:In recent years, it has become appreciated that immune cells have different metabolic profiles depending on their activation status. During sepsis, circulating leukocytes go through a hyperinflammatory state, which can be accompanied or followed by defective antimicrobial defenses (also described as immune tolerance o...

journal_title：Journal of leukocyte biology

authors： Arts RJ,Gresnigt MS,Joosten LA,Netea MG

更新日期：2017-01-01 00:00:00

abstract：:Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll-IL-1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune-mediated pathologies, including infection, chronic inflammat...

journal_title：Journal of leukocyte biology

authors： Schultz TE,Blumenthal A

更新日期：2017-01-01 00:00:00

abstract：:ANCA to either PR3 or MPO are found in patients with necrotizing vasculitis and glomerulonephritis. ANCA binding to their target antigens on neutrophils and subsequent neutrophil activation are pivotal disease mechanisms that lead to vascular inflammation and necrosis. ANCA interaction with PR3 is more complex than wi...

journal_title：Journal of leukocyte biology

authors： Schreiber A,Eulenberg-Gustavus C,Bergmann A,Jerke U,Kettritz R

更新日期：2016-12-01 00:00:00

abstract：:The scavenger receptor CD163 is exclusively expressed by monocyte/macrophages and is shed by matrix metalloproteinases (MMPs) and neutrophil elastase (ELA2) as soluble CD163 (sCD163). Monocyte phenotype is altered in diabetes, but the relationship among monocyte CD163, sCD163, and diabetic complications is not known a...

journal_title：Journal of leukocyte biology

authors： Min D,Brooks B,Wong J,Aamidor S,Seehoo R,Sutanto S,Harrisberg B,Yue DK,Twigg SM,McLennan SV

更新日期：2016-12-01 00:00:00

abstract：:Fetal alcohol spectrum disorder (FASD), which results from ethanol exposure during pregnancy, and alcohol use disorder (AUD), which includes both binge and chronic alcohol abuse, are strikingly common and costly at personal and societal levels. These disorders are associated with significant pathology, including that ...

journal_title：Journal of leukocyte biology

authors： Kane CJ,Drew PD

更新日期：2016-11-01 00:00:00

abstract：:The germinal center (GC) is a dynamic structure formed by proliferating B cells in the follicles of secondary lymphoid organs during T cell-dependent antibody responses to exogenous antigens. GC is composed by a dark zone, enriched in proliferating centroblasts (CBs), and a light zone where CBs migrate and transform i...

journal_title：Journal of leukocyte biology

authors： Ferretti E,Ponzoni M,Doglioni C,Pistoia V

更新日期：2016-11-01 00:00:00

abstract：:ADAM23 is a member of the brain macrophage-derived chemokine family. Structural homology of ADAM proteins suggests their function as integrin receptors. Previous studies have linked ADAM23 as a dominant contributor to brain development and cancer metastasis. The present studies now show that ADAM23 expression on DCs p...

journal_title：Journal of leukocyte biology

authors： Elizondo DM,Andargie TE,Marshall KM,Zariwala AM,Lipscomb MW

更新日期：2016-11-01 00:00:00

abstract：:The success of mesenchymal stem cell transplantation for proctitis depends not only on cell donors but also on host microenvironmental factors, which play a major role in conditioning mesenchymal stem cell immunosuppressive action and repair. This study sought to determine if flagellin, a TLR5 ligand, can enhance the ...

journal_title：Journal of leukocyte biology

authors： Linard C,Strup-Perrot C,Lacave-Lapalun JV,Benderitter M

更新日期：2016-09-01 00:00:00

abstract：:Immune-checkpoint blockade therapy with antibodies targeting CTLA-4 and PD-1 has revolutionized melanoma treatment by eliciting responses that can be remarkably durable and is now advancing to other malignancies. However, not all patients respond to immune-checkpoint inhibitors. Extensive preclinical evidence suggests...

journal_title：Journal of leukocyte biology

authors： Vilgelm AE,Johnson DB,Richmond A

更新日期：2016-08-01 00:00:00

abstract：:Successful remodeling of the uterine spiral arteries is essential for a complication-free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistoch...

journal_title：Journal of leukocyte biology

authors： Lash GE,Pitman H,Morgan HL,Innes BA,Agwu CN,Bulmer JN

更新日期：2016-08-01 00:00:00

abstract：:Alveolar macrophages from chronic obstructive pulmonary disease patients and cigarette smokers are deficient in their ability to phagocytose apoptotic bronchial epithelial cells (efferocytosis). We hypothesized that the defect is mediated via inhibition of sphingosine kinases and/or their subcellular mislocalization i...

journal_title：Journal of leukocyte biology

authors： Tran HB,Barnawi J,Ween M,Hamon R,Roscioli E,Hodge G,Reynolds PN,Pitson SM,Davies LT,Haberberger R,Hodge S

更新日期：2016-07-01 00:00:00

abstract：:The lymphotoxin signaling pathway plays an important role in the homeostasis and function of peripheral and mucosal dendritic cells, and dendritic cell-intrinsic lymphotoxin β receptor expression is required for optimal responses to opportunistic intestinal bacteria. However, it is unknown whether dendritic cell-intri...

journal_title：Journal of leukocyte biology

authors： Sun T,Rojas OL,Li C,Philpott DJ,Gommerman JL

更新日期：2016-07-01 00:00:00

abstract：:The triggering receptor expressed on myeloid cell locus encodes a family of receptors that is emerging as an important class of molecules involved in modulating the innate immune response and inflammation. Of the 4 conserved members, including triggering receptor expressed on myeloid cells 1 and 2 and triggering recep...

journal_title：Journal of leukocyte biology

authors： Thomas KA,King RG,Sestero CM,Justement LB

更新日期：2016-07-01 00:00:00

abstract：:Although endosomes, lysosomes, and phagosomes require a reductive environment for the optimal activity of disulfide reductases and other thiol-dependent enzymes, how these reductive environments are established and maintained remain unknown. Our goal in this study was to begin to elucidate the redox control systems re...

journal_title：Journal of leukocyte biology

authors： Balce DR,Greene CJ,Tailor P,Yates RM

更新日期：2016-07-01 00:00:00

abstract：:TNFR-associated periodic syndrome is an autoinflammatory disorder caused by autosomal-dominant mutations in TNFRSF1A, the gene encoding for TNFR superfamily 1A. The lack of knowledge in the field of TNFR-associated periodic syndrome biology is clear, particularly in the context of control of immune self-tolerance. We ...

journal_title：Journal of leukocyte biology

authors： Pucino V,Lucherini OM,Perna F,Obici L,Merlini G,Cattalini M,La Torre F,Maggio MC,Lepore MT,Magnotti F,Galgani M,Galeazzi M,Marone G,De Rosa V,Talarico R,Cantarini L,Matarese G

更新日期：2016-05-01 00:00:00

abstract：:Brucella abortus is a Gram-negative intracellular bacterial pathogen that causes a zoonosis of worldwide occurrence, leading to undulant fever in humans and abortion in domestic animals. B. abortus is recognized by several pattern-recognition receptors triggering pathways during the host innate immune response. Theref...

journal_title：Journal of leukocyte biology

authors： Gomes MT,Campos PC,Pereira Gde S,Bartholomeu DC,Splitter G,Oliveira SC

更新日期：2016-05-01 00:00:00

abstract：:Myeloperoxidase aids in clearance of microbes by generation of peroxidase-mediated oxidants that kill leukocyte-engulfed pathogens. In this review, we will examine 1) strategies for in vitro evaluation of myeloperoxidase function and its inhibition, 2) ways to monitor generation of certain oxidant species during infla...

journal_title：Journal of leukocyte biology

authors： Huang J,Milton A,Arnold RD,Huang H,Smith F,Panizzi JR,Panizzi P

更新日期：2016-04-01 00:00:00

abstract：:The Fanconi anemia proteins participate in a canonical pathway that repairs cross-linking agent-induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia-deficient hematopoietic stem cells are also hypersensitive to inflammatory cytokines, and, as imp...

journal_title：Journal of leukocyte biology

authors： Garbati MR,Hays LE,Rathbun RK,Jillette N,Chin K,Al-Dhalimy M,Agarwal A,Newell AE,Olson SB,Bagby GC Jr

更新日期：2016-03-01 00:00:00

abstract：:HLA-E is a nonclassical HLA-class I molecule whose best known role is to protect from the natural killer cells. More recently, an additional function more similar to that of classical HLA-class I molecules, i.e., antigen presentation to T cells, is emerging. However, much remains to be explored about the intracellular...

journal_title：Journal of leukocyte biology

authors： Camilli G,Cassotta A,Battella S,Palmieri G,Santoni A,Paladini F,Fiorillo MT,Sorrentino R

更新日期：2016-01-01 00:00:00

abstract：:p67(phox) is the paramount cytosolic regulator of the superoxide-generating Nox of phagocytes, by controlling the conformation of the catalytic component, Nox2. The initiating event of this process is a protein-protein interaction between p67(phox) and the part of Nox2 protruding into the cytosol, known as the dehydro...

journal_title：Journal of leukocyte biology

authors： Dahan I,Smith SM,Pick E

更新日期：2015-11-01 00:00:00

abstract：:Endotoxin tolerance is characterized by diminished expression of inflammatory cytokines after sequential exposure to Toll-like receptor stimuli. Many mechanisms contribute to tolerance; however, chromatin remodeling appears to be the most significant regulator. The type II interferon, IFN-γ, has been recognized as bei...

journal_title：Journal of leukocyte biology

authors： Shi L,Song L,Maurer K,Sharp J,Zhang Z,Sullivan KE

更新日期：2015-10-01 00:00:00

abstract：:It is well established that the cytokine IL-12 and the transcription factor STAT4, an essential part of the IL-12 signaling pathway, are critical components of the Th1 differentiation process in T cells. In response to pathogenic stimuli, this process causes T cells to proliferate rapidly and secrete high amounts of t...

journal_title：Journal of leukocyte biology

authors： Schaller M,Ito T,Allen RM,Kroetz D,Kittan N,Ptaschinski C,Cavassani K,Carson WF 4th,Godessart N,Grembecka J,Cierpicki T,Dou Y,Kunkel SL

更新日期：2015-10-01 00:00:00

abstract：:CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by macrophages in lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last de...

journal_title：Journal of leukocyte biology

authors： Sanjurjo L,Aran G,Roher N,Valledor AF,Sarrias MR

更新日期：2015-08-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs), web-like DNA structures, provide efficient means of eliminating invading microorganisms but can also present a potential threat to its host because it is a likely source of autoantigens or by promoting bystander tissue damage. Therefore, it is important to identify mechanisms tha...

journal_title：Journal of leukocyte biology

authors： Zabieglo K,Majewski P,Majchrzak-Gorecka M,Wlodarczyk A,Grygier B,Zegar A,Kapinska-Mrowiecka M,Naskalska A,Pyrc K,Dubin A,Wahl SM,Cichy J

更新日期：2015-07-01 00:00:00

abstract：:2-Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids that have been implicated in many physiologic disorders, including obesity, metabolic syndromes, hepatic diseases, pain, neurologic disorders, and inflammation. Their immunomodulatory effects are numerous and are not always mediated...

journal_title：Journal of leukocyte biology

authors： Turcotte C,Chouinard F,Lefebvre JS,Flamand N

更新日期：2015-06-01 00:00:00

abstract：:IL-33 is a more recently identified member of the IL-1 cytokine family, expressed in the nucleus of epithelial cells and released into the extracellular space following tissue damage. The impact of IL-33 as a regulator of the adaptive immune response has been studied extensively, with an understood role for IL-33 in t...

journal_title：Journal of leukocyte biology

authors： Lott JM,Sumpter TL,Turnquist HR

更新日期：2015-06-01 00:00:00

abstract：:CD137 ligand (CD137L) is expressed on APCs and crosslinks CD137, a powerful costimulatory molecule on T cells during cognate interactions, and thereby greatly enhances immune responses. We report that CD137 can be transferred from activated T cells and from tumor cells that express CD137 to other cells via trogocytosi...

journal_title：Journal of leukocyte biology

authors： Shao Z,Harfuddin Z,Pang WL,Nickles E,Koh LK,Schwarz H

更新日期：2015-05-01 00:00:00

abstract：:NLRP3 is the most crucial member of the NLR family, as it detects the existence of pathogen invasion and self-derived molecules associated with cellular damage. Several studies have reported that excessive NLRP3 inflammasome-mediated caspase-1 activation is a key factor in the development of diseases. Recent studies h...

journal_title：Journal of leukocyte biology

authors： Lin YC,Huang DY,Wang JS,Lin YL,Hsieh SL,Huang KC,Lin WW

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes to regulating innate immune response to ACs by inhibiting DC activation in ...

journal_title：Journal of leukocyte biology

authors： Cabezón R,Carrera-Silva EA,Flórez-Grau G,Errasti AE,Calderón-Gómez E,Lozano JJ,España C,Ricart E,Panés J,Rothlin CV,Benítez-Ribas D

更新日期：2015-04-01 00:00:00

abstract：:TTP is an anti-inflammatory protein that acts by binding to AREs in its target mRNAs, such as Tnf mRNA, and promoting their deadenylation and decay. TNF released from inflammatory cells can then stimulate gene expression in tissue cells, such as fibroblasts. To determine whether TTP could affect the decay of TNF-induc...

journal_title：Journal of leukocyte biology

authors： Qiu LQ,Lai WS,Bradbury A,Zeldin DC,Blackshear PJ

更新日期：2015-04-01 00:00:00

abstract：:Most staphylococci produce short α-type PSMs and about twice as long β-type PSMs that are potent leukocyte attractants and toxins. PSMs are usually secreted with the N-terminal formyl group but are only weak agonists for the leukocyte FPR1. Instead, the FPR1-related FPR2 senses PSMs efficiently and is crucial for leuk...

journal_title：Journal of leukocyte biology

authors： Kretschmer D,Rautenberg M,Linke D,Peschel A

更新日期：2015-04-01 00:00:00